Peptide Therapy

Peptide therapy is the medicne of the 21st century! Riding the fence between traditional pharmaceutical medications and nutraceuticals, peptides are small amino acid sequences which provide vital information for human and mammalian cells for producing essential hormones, improving glucose utilization, addressing brain health, repairing nerves and wounds, healing the gut, supporting hair growth, enhancing skin appearance and elasticity, increasing deep sleep, and even lengthening telomeres.

These peptides recommended by the practitioners of AIM are available from FDA approved, GMP pharmacies. However, some of these peptides are still waiting for full inclusion as approved items for prescription by US physicians. Many of these peptides, while traditionally used as injectables, can be taken sublingually as a stack.

ARA 290

Benefits: Peripheral neuropathy, burns, frostbite, TBI, post-op, diabetic neuropathy

Dosing: Inject 4mg 3 to 5 x week for 5 weeks

In office, use with neural therapy (procaine and bicarb) along meridian lines of fascia

 

BPC 157

Benefits: Tissue and wound healing, gut repair, increases stem cells, antioxidant, increases GH, improves nitric oxide, angiogenesis

Dosing: Inject 500mcg daily for 30 days or 300 to 500mcg bid or take orally 500mcg per day x 30 to 60 days

Add KPV for extra support in gut

 

Cerebrolysin – Combo of 6 peptides (BDNF, NGF, Enkephalin, Orexin, CNGF, P21)

Benefits: Cognitive recovery, post stroke, TBI, Alzheimer’s, migraines, Parkinson’s, ADHD, lowers glutamate toxicity, induces neuroplasticity, antioxidant

Dosing: IV 10 to 50 ml (215mg/ml) in 100 to 500 cc NS or inject 1ml subq daily

Best if used in acute to subacute TBI

For Dementia, use daily for 4 weeks

Risks: Don’t mix with other peptides, risk of seizures in epilepsy patients, can lead to loss of appetite, nausea

 

CJC-IPROMORELIN 2mg/2ml

Benefits: Increases GH (3x better than Sermorelin), increases fat burning, increased sex drive, weight loss

Dosing: Inject 5 to 10 units 5 days per week, best on empty stomach

Or CJC-DAC

Dosing: Inject 600mcg 1x week

Longer half life (6 days)

More risk because it limits natural GH spike at 1am

*Due to risk factors, AIM does not supply or recommend this specific peptide CJC-DAC

CJC in any form is banned by WADA (World Anti-Doping Agency) – not allowed for college or pro athletes

Avoid with Cancer diagnosis or risk

 

DiHexa

Benefits: Cognition, Alzheimer’s, Parkinson’s, Improves cerebral blood flow, 7x more powerful than BDNF

Dosing: 20mg/ml cream – 1ml to inner forearms daily or 10mg or 20mg pill- 10 to 40mg orally per day

Side effects can include nervousness, Irritability

 

DSIP

Benefits: Sleep promotion, neuroprotection, alcohol and drug withdrawal and detox

Dosing: 1mg/ml – 10 to 20 units (100 to 200mcg /subq) at bedtime or can be used sublingual

Side effects might include vertigo, nausea, headache

 

Epitalon 10mg

Benefits: Lowers corticosteroids, synthetic pineal gland, antiaging, lengthens telomeres, tumor protective, maintains hormone balance, antioxidant, lowers LDL and VLDL, increases HDL, improves insulin sensitivity, improves sleep

Dosing: 10 to 20mg orally 2x day 30 min before meals x 1 month or inject 10mg subq every 3 days for 15 days (2x year) or can be used sublingual

 

FOXO4-DRI 10mg/ml

Benefits: Senolytic (eats unwanted zombie cells), treats male onset hypogonadism, counters chemo induced hepatocellular senescence, renal protection, longevity, binds p53, improves testosterone

Dosing: 40 units subq every 3 days for 4 to 6 weeks, repeat 3x year, or can be used sublingual

*Make sure to get TFA free

 

Fx

Benefits: Actin binding peptide, sports injury, cardiovascular repair post MI, post stroke, NAFLD, isolated from calf thymus, immune repair

Doing: 300mcg to 1 mg per day injected subq for 3 mos max

*Avoid for use for more than 3 months without cycling off 3 months

Prohibited by WADA (World Anti-Doping Agency) – not allowed for college or pro athletes

 

GHK- CU

Benefits: Antiaging, skin regenerative, tissue repair, improves skin elasticity and firmness, UV protection, hair growth

Dosing: 1-2mg IM per day for 21 days max, or 5mg sublingual per day for 3 weeks (in liposomal form)

Also available as a scalp foam 0.5% 50 ml for hair growth – apply daily with massage

*Take with zinc 30 to 50mg per day, stop after 3 to 4 weeks. If luna of nails turn blue, stop immediately (will correct in 4 weeks if you avoid copper in diet)

 

Humanin

Avoid if cancer risk, or active cancer, especially hormone based cancers

*Due to risk factors, AIM does not supply or recommend this specific peptide Humanin

 

KPV

Benefits: Use with BPC157 for gut healing, immune modulation, inflammation

Dosing: 500mcg 2x day or liposomal tab 250 mcg 2 x day

 

LL37 2000mcg/ml

Benefits: Antimicrobial, antiviral, mold, biotoxins, chronic wounds, venous ulcers

Dosing: 200mcg (10 units) subq daily for 6 to 8 weeks

Topically LL37 gel can be applied to wounds 2 to 3x week, can also be used sublingual

Take with Vit D3

Be careful with cancer or those at risk of cancer or autoimmune conditions

*Due to risk factors, AIM does not supply or recommend this specific peptide LL37

 

Larazotide 500mcg

Benefits: Leaky gut, improves tight junctions, IBS, Crohn’s, colitis, celiac disease

Dosing: 2 to 3 x daily before meals

 

Melanotan II 2mg/ml

Benefits: Tanning effects, increases libido, immune support, metabolic support

Dosing: 300mcg subq daily (15 units) for 1 for 2 weeks then 25 units 2x week

Avoid if family history of melanoma, stop if experiencing nausea or vomiting

*Due to risk factors, AIM does not supply or recommend this specific peptide Melanotan II

 

Met-Enkephalin

Benefits: Opioid growth factor, antinociceptive (pain blocking), stress support, substance use, metabolic support

Dosing: 5mg subq 3x week, max 10mg subq twice a day, or IV 250mcg/kg over 30 minutes weekly, or can also be used sublingual

 

PEG-MGF (aka Mechano-Growth Factor, IGF-1)

Avoid using this peptide because it is attached to PEG (polyethylene glycol) which is toxic to the nervous system cells. You can use MGF (aka IGF-1) as a peptide by itself but its half-life is only a few minutes so it will not have a lasting effect.

*Due to risk factors, AIM does not supply or recommend this specific peptide PEG-MGF

 

MOTS-c (Mitochondrial-derived peptide)

Benefits: Weight loss and diabetes therapy, Anti-aging, Cytoprotective, Mitochondrial enhancement, Metaflammation, AMPK activation, increased glucose uptake into muscle, increases intracellular NAD+, increases sirtuins, lowers triglycerides, enhances bone health and strength

Dosing: 5-10 mg subq 2x/week or can also be used sublingual

Targets folate cycle so it is advisable to supplement with 5-MTHF, folate, or folinic acid up to 1200mcg daily; also check homocysteine levels prior to taking MOTS-c.

 

OS-01 (AMPK activator)

Benefits: AMPK activation, increases autophagy, renal protection (AMPK activated in kidney), metabolic support, increases fatty acid metabolism, lipolysis, increased ATP production, pain modulation (AMPK decrease pain hypersensitivity)

Dosing: 100mg daily by mouth for 4-6 weeks

 

PNC27 5000mg/ml

Benefits: Cancer support, induces tumor cell necrosis and membranolysis, decreases LDH, cytotoxic effects for human primary cancer cells including those of the prostate, pancreas, myelomas, breast, cervix, ovary, colon, white blood cells (leukemias)

Dosing: 0.2 ml (20 units) to 0.4 ml (40 units) 3x a day for 6 weeks

If metastasis, increase to up to 24 weeks

*AIM does not supply or recommend this specific peptide PNC27

 

PT141 (Alpha-Melanocortion Receptor Agonist) 20mg/2ml vial

Dosing: 2mg (0.2 ml or 20units) 45-60 min before sex. Start with 0.1 ml (10 units) for test dose then add 0.1ml (10 units) 30 min later. Do a max of 2x/weekly.

Available in Vyleesi and approved by insurance to treat women with hypoactive sexual desire disorder (HSDD) in women

Risks: GI distress, flushing, headache, nausea, vomiting, tachycardia, priapism (men), hyperpigmentation of skin. Avoid using with PDE5 inhibitors (Viagra, Cialis) due to risk of hypertension and priapism

*Due to risk factors, AIM does not supply or recommend this specific peptide PT141

 

Selank (Tuftsin mimetic, anxiolytic)

Benefits: Anxiolytic, affects GABA but no hangover or addiction, supports cognition, supports immune function, adaptogenic, lowers inflammation, helps with gastric ulcers, helps turn off autoimmunity, improves BDNF

Dosing: 300-1000mcg daily subq or 2x/weekly (on alternating days with Semax), can also be used sublingual or intranasally

Avoid using with anti-anxiety medications (eg. Valium, Ativan, Xanax) or psychotropics

 

Semax (ACTH 4-10 fragment of adrenocorticotropic hormone)

Benefits: Neuroprotective, decreases glutamate neurotoxicity, stabilizes mitochondria, increases trophic supply to the brain, limits the effects of oxidative stress, protects the optic nerve, helps with chronic stress, pain management-prevents enkephalin breakdown, antidepressant effects, useful in TBI, post-stroke/TIA, Alzeheimer’s, acute MI, heavy metal toxicity, memory enhancement

Dosing: 300-1000mcg subq daily or 2x/weekly, can also be used sublingual or intranasally

 

Semaglutide (Glucagon-like peptide)

Side effects: diabetic retinopathy, pancreatitis, hypoglycemia, thyroid cell tumors, acute kidney injury, hypersensitivity reactions

*Due to risk factors, AIM does not supply or recommend this specific peptide Semaglutide or any of its analogues (Tirzepaptide, Wegovy, Ozempic). AIM does not offer Semaglutide (Ozempic) or any similar peptides including Wegovy, Mounjaro, or Sepbound.

See research articles below

Sermorelin (Growth hormone releasing peptide 1-29)

Benefits: Binds to growth hormone releasing factors in the pituitary gland, improves regeneration potential and wound healing, improves outcomes after orthopedic procedures, improves muscle strength, improves calcium retention in bones, improves fat burning, improves skin quality and collagen density, improves athletic performance, increases fat utilization/burning, improves libido, improves sleep

Dosing: 200-300mcg subq per day before bedtime 5 days/week for 2 months, can also be used sublingual with glycine 5 days/week for 2 months

Originally approved for treatment of growth hormone deficiency in children in 1997 but found out to be more effective in adults

Risks: patients can develop anti-GRF antibodies during treatment (anti-hypothalamic growth hormone releasing factor)

Prohibited by WADA (World Anti-Doping Agency) – not allowed for college or pro athletes

 

SS-31 (Mitochondrial peptide)

Benefits: Scavenges reactive oxygen species, improves mitochondrial function, improves ATP production, decreases the mitochondrial permeability that occurs with stressors such as TBI, stroke, Parkinson’s and Alzheimer’s diseases, benefits with aging, atherosclerosis, macular degeneration, diabetes, glaucoma, improves cardiac hypertrophy, dialstolic dysfunction and scar tissue in heart, restores mitochondrial structure in kidneys, reduces LPS in brain

Dosing: 40mg subq daily for 12 weeks, or 10-50 mg sublingual per day for 12 weeks

 

Tesamorelin

Benefits: Increases IGF-1, improves cognitive function, improves axonal damage, decreases visceral fat

Dosing: 1-2 mg subq daily 90 min before bed or 30 min after last food intake

Prohibited by WADA (World Anti-Doping Agency) – not allowed for college or pro athletes

Risks: hypersensitivity reactions, pregnancy, pituitary disorders, active malignancy, disruption of HPA axis, neoplasms, elevated IGF-1, cytochrome p-450 upregulation,

*Due to risk factors, AIM does not supply or recommend this specific peptide Tesamorelin

 

Thymosin alpha-1

Benefits: Immune support, hepatitis B, C, Viral illness, chemotherapy adjunct, Lyme disease, cystic fibrosis, DiGeorge’s syndrome, chronic inflammatory conditions, autoimmunity, decreases T-cell apoptosis, inhibits viral replication, improves CD3+, CD4+, CD8+, modulates innate immunity, improves cellular glutathione

Dosing: 1.5 mg subq 2x/week for 2 to 12 weeks, can also be used sublingual in liposomal form

 

Thymosin beta 4 (TB4, TB-500)

Benefits: Sports injury, cardioprotective–especially post-MI, neuroinflammation, immune support, soft-tissue repair, spinal cord injury, diabetic retinopathy, corneal injury, dry eye, sepsis, chemical burns, NAFLD, isolated from calf thymus, upregulates actin, promotes MMP during wound repair, decreases scar formation

Dosing: 300mcg to 1g subq daily for 12 weeks then cycle off for 6 weeks, then on for 6 weeks, can also be used sublingual or intranasally

 

Thymulin

Benefits: Dependent on zinc status; take with zinc 30 to 50 mg /day (recommend RBC zinc lab to access zinc levels), immune support, analgesic, anti-inflammatory, neuroinflammation

Dosing: 1mg subq daily for 2 weeks then 1mg 3x/week for 4 months, can also be used sublingual in liposomal form

 

Tirzepaptide (glucagon agonist, GLP-1)

Same side effects as Semaglutide

Side effects: diabetic retinopathy, pancreatitis, hypoglycemia, thyroid cell tumors, acute kidney injury, hypersensitivity reactions

*Due to risk factors, AIM does not supply or recommend this specific peptide Semaglutide or any of its analogues (Tirzepaptide, Wegovy, Ozempic)

AIM does not offer Semaglutide (Ozempic) or any similar peptides including Wegovy, Mounjaro, or Sepbound.

TP508 (Thrombin Peptide)

Benefits: Wounds including diabetic foot ulcers, vascular damage, radiation damage

Dosing: 10-30 mcg subq at site of injury

Due to risk factors of blood clotting, AIM does not supply or recommend this specific peptide (TP508) except in acute wound healing during first 24 hours

 

VIP (Vasoactive Intestinal Peptide)

Benefits: Gut-brain axis support, improves intestinal barrier, CNS protection, CIRS and biotoxin illnesses, pulmonary hypertension, increases Zonulin 1 (helpful for ulcerative colitis or Crohns disease), respiratory illness, maintains BBB

Dosing: 50mcg/ml – start 1 spray alternating nostrils to max of 8 sprays/day

Keep refrigerated

Risks: hypotension, can affect pancreatic function (recommend fasting lipase every 4 weeks)