Prolotherapy and Prolozone for Colorado Patients
Prolotherapy and Prolozone Are Used to Treat:
- Knee, Foot or Ankle Pain
- Shoulder (Rotator Cuff) Injury
- Sacroiliac or SI Joint (SIJ) Pain
- Osteoarthritis Pain
- ACL Injuries
- Neck, Upper and Lower Back Pain
- Regional Pain Syndrome (RSD)
- Degenerative Disc Disease (DDD)
- Tennis / Golfer’s Elbow
- Wrist and Hand Pain
- Cervicogenic Headaches
- Myofascial Pain Syndromes
- Hip or Groin Sprain
- Sciatica and Temporomandibular Joint (TMJ)
- Spondylosis (Spinal Osteoarthritis)
What Is Prolotherapy?The “prolo” in prolotherapy is derived from the word “proliferation,” as the therapy is intended to proliferate tissue growth in the damaged area. This is also called regenerative injection therapy (RIT) because the treatment extends beyond the proliferative stage, which is only the second stage of the regenerative healing process. Prolotherapy is an injection technique that has been shown to stimulate cell growth, stabilize tissue, and strengthen weakened joints, cartilage, ligaments and tendons. Prolotherapy injections rebuild and strengthen the complete joint structure, even in patients with no cartilage. This non-surgical injection therapy may eliminate the need for joint replacement, which usually requires a recovery time of three or more months and costs thousands.* Prolotherapy can be effective because it addresses and eliminates the cause of chronic pain arising from connective tissue such as ligaments, tendons and cartilage. *Results may vary; no guarantee of specific results
How Does Prolotherapy Work?Prolotherapy works by causing a temporary, low grade inflammation at the injection site, activating fibroblasts to the area, which, in turn, synthesize precursors to mature collagen and thus reinforce connective tissue. It has been well documented that direct exposure of fibroblasts to growth factors (either endogenous or exogenous) causes new cell growth and collagen deposition. Inflammation creates secondary growth factor elevation. The inflammatory stimulus of prolotherapy raises the level of growth factors to resume or initiate a new connective tissue repair sequence which had prematurely aborted or never started. Animal biopsy studies show ligament thickening, enlargement of the tendinosseous junction, and strengthening of the tendon or ligament after prolotherapy injections (Alderman, 2015).
What Is Prolozone? How Is It Different from Prolotherapy?While prolozone therapy is similar to prolotherapy in that it also involves regenerative injections, prolozone injections contain less dextrose and therefore typically produce less inflammation. Prolozone also includes the injection of ozone into the tissue, which increases the blood supply and flow of healing nutrients while stimulating the deposition and activity of fibroblasts and chondroblasts. These cells synthesize the collagen and cartilage that the body uses to repair damaged ligaments and joints. The prolozone injections increase cellular repair activity to strengthen and tighten the injured tissues; thereby stabilizing the area, and removing the cause of the pain. Ozone is a naturally occurring, highly reactive molecule consisting of three atoms of oxygen. Because ozone is so reactive, it is able to heavily stimulate fibroblastic and chondroblastic activity. This high level of reactivity, combined with the innate safety of oxygen, makes ozone a highly therapeutic molecule.
Of note, Dr. Hughes’ primary rationale for use of injected ozone, alongside its benefits to mitigate pain, is its safe and highly potent antimicrobial effects as part of sterile technique.
What Is the Technique for Prolotherapy Injections?1. The prolotherapy injection is placed into the damaged ligament or tendon at the point where it attaches to the bone. 2. The injection produces an inflammation, which increases blood flow, swelling and pain. 3. The body then launches a course of repair and healing. The inflammation tricks the body into thinking another injury has occurred, so it sends in macrophages, which are cells that ingest and destroy the irritant solution. These cells clean up the area. 4. The body then sends in fibroblasts, which are cells that help build fibrous tissue. 5. The fibroblasts excrete collagen, a protein that makes the ligaments denser and stronger. The stronger ligaments provide more support for the joints and alleviate the pain.* *Results may vary; no guarantee of specific results
Frequently Asked Questions About Prolotherapy:
How Do I Prepare for Prolotherapy Injections?
Is Prolotherapy Painful? Is Medication Needed Beforehand?
What Else Should I Expect During the Prolotherapy Procedure?
How Long Does It Take for Prolotherapy to Work?
What Is Recommended for Recovery and Exercise After Prolotherapy?
Will Prolotherapy Increase My Inflammation?
Will Prolotherapy Lock Up My Back Muscles?
Is Prolotherapy Covered by Insurance?
How Much Does Prolotherapy Cost?
Sagai, M., & Bocci, V. (2011). Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress? Medical Gas Research, 1, 29. http://doi.org/10.1186/2045-9912-1-29