Adult stem cells
Development of a multicellular organism is accomplished through a series of events that are preprogrammed in the genome. These events encompass cellular proliferation, lineage commitment, lineage progression, lineage expression, cellular inhibition, and regulated apoptosis. The sequential progression of cells through these events results in the formation of the differentiated cells, tissues, and organs that constitute […]
Adult reserve stem cells & their potential for tissue engineering
Tissue restoration is the process whereby multiple damaged cell types are replaced to restore the histoarchitecture and function to the tissue. Several theories have been proposed to explain the phenomenon of tissue restoration in amphibians and in animals belonging to higher orders. These theories include dedifferentiation of damaged tissues, transdifferentiation of lineage-committed progenitor cells, and […]
Mesenchymal stem cells are susceptible to human herpesviruses, but viral DNA cannot be detected in the healthy seropositive individual
Allogeneic stem cell transplantation is often complicated by reactivation of herpesviruses. Mesenchymal stem cells (MSC) are immunomodulatory and may be used to treat graft-versus-host disease. We investigated if herpesviruses infect and can be transmitted by MSC, and if MSC suppress immune responses to various infectious agents. Mesenchymal stem cells from healthy seropositive donors were evaluated […]
Primitive stem cells residing in the skeletal muscle of adult pigs are mobilized into the peripheral blood after trauma
This study was designed to determine if trauma causes the release of adult-derived blastomere-like stem cells (BLSCs) from skeletal muscle into the circulating blood of adult pigs. Experimental procedures followed the guidelines of Fort Valley State University’s Institutional Animal Care and Utilization Committee. Pigs were traumatized by splenectomy followed by pancreatectomy. Blood samples and skeletal […]
Very small embryonic-like stem cells: characterization, developmental origin, and biological significance
Bone marrow (BM) was, for many years, primarily envisioned as the “home organ” of hematopoietic stem cells (HSC). Augmenting evidence demonstrates, however, that BM, in addition to HSC, also contains a heterogeneous population of non-HSC. Recently, our group identified in BM and other adult tissues a population of very small embryonic-like stem cells (VSELs), which […]
Mesenchymal stem cells as therapeutics
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a new therapeutic for treating a variety of immune-mediated diseases. First heralded as a regenerative therapy for skeletal tissue repair, MSCs have recently been shown to modulate endogenous tissue and immune cells. Preclinical studies of the mechanism of action suggest that the […]
What Are Multipotent Stem Cells?
Multipotent stem cells have the same basic features of all stem cells. As with all stem cells multipotent stem cells are unspecialized cells that have the ability to: Self-renew for long periods of time and differentiate into specialized cells with specific functions A multipotent stem cell can give rise to other types of cells but […]
What is Mesenchyme?
Mesenchyme is a type of animal tissue comprised of loose cells embedded in a mesh of proteins and fluid, called the extracellular matrix. The loose, fluid nature of mesenchyme allows its cells to migrate easily and play a crucial role in the origin and development of morphological structures during the embryonic and fetal stages of animal life. […]
Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes
Glomerulonephritis (GN) is a major cause of renal failure. This study sought to determine whether intrarenal injection of rat mesenchymal stem cells (MSC) can preserve renal function in a progressive rat model of GN. Early in GN (day 10), fluorescently labeled rat MSC localized to more than 70% of glomeruli, ameliorated acute renal failure, and […]
Adult Stem Cells Scientific References
Cell Applications. https://www.cellapplications.com/stem-0 Cellular Differentiation. http://oerpub.github.io/epubjs-demo-book/content/m46036.xhtml Kunter, U., Rong, S., Boor, P., Eitner, F., Müller-Newen, G., Djuric, Z., … & Milovanceva-Popovska, M. (2007). Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes. Journal of the American Society of Nephrology, 18(6), 1754-1764. MacCord, K. (2012). Mesenchyme. The Embryo Project Encyclopedia. Retrieved from https://embryo.asu.edu/pages/mesenchyme Mesenchymal Stem Cell […]