The Miracle Molecule

Nitric oxide is a signaling molecule and a gas. It tells the arteries to relax, which improves circulation and blood flow. The discovery of this “miracle molecule” won the Nobel Price in 1998 and was named “Molecule of the Year” in 1992.

Nitric oxide carries messages at the cellular level, able to efficiently penetrate cellular membranes because of its gaseous structure. N-O is abundant in the body, but it is unstable and short-lived, and thus must be renewed continuously. A large and growing body of research points to nitric oxide’s broad impact on health, even traumatic brain injuries.

It has been found that nitric oxide improves support for circulation and blood flow and has been linked to a variety of health benefits, including helping:

  • Support healthy blood pressure levels
  • Support cardiovascular and heart health
  • Promote increased circulation throughout the body
  • Support normal, healthy circulation
  • Support healthy arterial function
  • Promote artery dilation for healthy blood flow

Nitric oxide (NO) science remains the “hottest” subject in the medical literature because its fundamental roles in human physiology are continually being uncovered. Of late, researchers have acknowledged that the human respiratory cycle involves much more than inhaling oxygen and exhaling carbon dioxide (waste).Our most basic need for oxygen is actually a complex NO-dependent process, making NO the third major blood gas in the respiratory cycle. As part of this three-gas system, NO will eventually be integrated into standard patient care and be monitored and manipulated via respiratory therapy along with oxygen and carbon dioxide.

Red Blood Cells Transport NO

Hemoglobin is the protein in red blood cells (RBCs) that loads up oxygen from the lungs for transport to cells. NO is also bound to hemoglobin, and when released, it expands the blood vessels to ensure successful oxygenation of cells.

Recently published research supports the fact that what determines the efficiency of oxygen delivery is blood flow in the body’s tiny capillaries, or microcirculation, as opposed to the total oxygen saturation of blood. That makes NO regulation of blood flow, equally, if not more important, than the blood’s oxygen content.
In one study investigation, researchers used engineered mice that lacked the ability to carry NO in their red blood vessels. These mice could not oxygenate their muscle tissue due to a lack of NO-regulated blood flow. Therefore, even though their RBCs were able to carry a full load of oxygen, they could not unload it. In normal mice, oxygen deficiency prompts vasodilation, allowing more oxygenated blood to reach tissues. But this response was absent in the mice whose RBCs lacked NO.

These findings help explain why many cardiovascular patients are not helped – and are possibly harmed – by blood transfusions or drugs such as erythropoietin that boost RBC production. Stored blood from a blood bank may lack NO, and evidence indicates that this likely increases the risk of heart attack and death in vulnerable patients. These problems have led to the suggestion that the nation’s blood supply should be replenished with NO.

Restoring NO

Expansive NO research continues to clarify our understanding of human physiology while it simultaneously outdates our textbooks. The body has the ability to maintain its own health when healthy signals from the right molecules are provided. NO is a fundamental molecule in human physiology and sends appropriate signals to cells in organ systems. It plays one of its most critical roles in the respiratory cycle – that of ensuring life-sustaining oxygenation.

There are constant insults to the production of NO in modern-day living that challenge our ability to stay sufficiently healthy. Restoring healthy signaling through direct NO repletion provides a support bridge to recovery. Researchers understand that NO holds the potential for addressing many human disorders.

We are indeed fortunate that the ability to replenish NO levels already exists in the form of Neo40®. As the Neo40® lozenge dissolves, tests show that it generates actual NO gas at a concentration of approximately 25-30 ppm. The multi-patented NO-generating technology in Neo40® is singularly unique and supported by five clinical trials that verify its efficacy. Neo40® is credited with countless positive testimonials that report remarkable quality-of-life improvements in health. Years ahead in transforming lives through restoring NO bioavailability, Neo40® represents the prototype for the future of NO medicine.


  1. Paddock, C. (2015, April 13). “Study shows blood cells need nitric oxide to deliver oxygen.” Medical News Today. Retrieved from source.
  2. McMahon TJ, et al. Nature Medicine. 2002;8:711-717.
  3. Reynolds JD, et al. PNAS. 2013;110(28):11529-34.