Regeneration and Exosomes
Exosomes are potent regenerative components derived from cells that enhance the delivery of peptides, nutrients, and biologics. They also possess regenerative properties themselves.
Under specific physiological conditions, exosomes exhibit very low immunogenicity and have the potential to cross the blood-brain barrier.
The most common method of administration is intravenous (IV), though it is rapidly cleared by the liver and kidneys in this form. This method has been widely used in treating conditions related to orthopedic, neoplastic, and cardiovascular diseases.
Exosomes are nanoscale, spherical extracellular vesicles with a lipid bilayer membrane, serving as intercellular messengers. These vesicles are considered miniature versions of their parent cells, as exosomes from a particular cell type carry specific biomolecules unique to that cell. Additionally, stem cells have been shown to act in a paracrine manner, releasing soluble factors, including exosomes. In other words, stem cell-derived exosomes (SC-Exo) carry therapeutic properties similar to their parent cells, such as anti-inflammatory effects, immunomodulation, and tissue regeneration.
Research:
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- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792642/
- https://www.ajkd.org/article/S0272-6386(24)00690-5/abstract
- https://academic.oup.com/ckj/article/17/1/sfad276/7342461
- https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Klotho-Cognitive-Vitality-For-Researchers.pdf
- https://classic.clinicaltrials.gov/ct2/show/NCT05293535
- https://peterattiamd.com/denadubal/
- https://www.linkedin.com/posts/samuel-miron-21098a2a5_exosomes-improve-the-delivery-of-peptides-activity-7231269522979106816-QSCc?utm_source=share&utm_medium=member_ios