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1. Adult Stem Cells for Chronic Pain Dr. John Hughes, DO January 24th, 2018

2. Dr. John Hughes, DO • Doctor of Osteopathy • From Georgia • Arizona College of Osteopathic Medicine – 2007 • Aspen Integrative Medicine – 2009 • TBI Therapy – 2014

3. Outline • What Are Stem Cells? • What Are Growth Factors? • How to Treat Chronic Pain

4. What Are Stem Cells? Defined Undifferentiated biological cells Divide and generate all cell types of the organ from which they originate Stimulate tissue re-growth and greater blood flow to the affected areas

5. • Mostly derived from embryos that develop from eggs in vitro • Expensive • Not autologous • Ethically controversial • Not readily available – research only What Are Stem Cells? Embryonic

6. • For the specific tissue or organ in which they live • Lung – Lung • Heart – Heart • Do not self-renew as easily • Difficult to find What Are Stem Cells? Tissue-Specific

7. • From bone marrow, fat, and cord blood • Immunomodulatory properties • On a development trajectory towards specific target tissues • Therapeutic effects are short- lived What Are Stem Cells? Mesenchymal

8. • Recently discovered in peripheral blood • Behave like embryonic stem cells • Give rise to all the cell types • Long lifespan What Are Stem Cells? Pluripotent

9. Stem Cell Potency Totipotent *Pluripotent* Multipotent Embryonic Peripheral Blood Mesenchymal

10. Stem Cell Uses Embryonic Peripheral Blood Mesenchymal • Research • Degenerative Diseases • Degenerative Diseases: • Diabetes • Osteoarthritis • Osteoporosis • Alzheimer’s Disease • Regeneration: • Brain Injuries • Joint/Ligament Repair • Anti-aging • Post Cancer Treatment • Fertility • Same tissue Replacement • Systemic Inflammatory Conditions

11. What Are Growth Factors? • Signaling molecules between cells • Cytokines and hormones that bind to specific receptors • Promotes cell differentiation and maturation

12. Stem Cells and Growth Factors • Stem cells = seeds • Growth factors = water/soil/fertilizer/sunlight • Without growth factors, the seed cannot mature and grow

13. What Do Growth Factors Do? • Designed to improve metabolism of nutrients • Stimulate growth of collagen: cartilage, bone, ligaments, tendons, blood vessels, and neurons • Guide stem cells to area of injury • Nurture stem cells to maturity

14. Growth Factors + Stem Cell Uses • Chronic Sports Injuries (ex. Tennis Elbow, Achilles Tendonitis, and Runner’s Knee) • Degenerative Joint & Disc Disease • Chronic Sprains and Strains • Cervical, Thoracic, and Lumbar Spine Strains • Traumatic Brain injuries • Arthritic Joints • Shoulder Pain, Hip Pain, and Knee Pain • Ligament Laxity or Tears • Tendon and Ligament Injuries • Carpal Tunnel Syndrome

15. How to Treat Chronic Pain • Surgery – expensive, risky, potential side effects • Physical Therapy – only manages pain, therapeutic but not long term • Cortisone Injections – temporary fix, manages inflammation, rarely solves source of pain, potentially damaging • Regenerative Injection Therapy – natural, autologous, treats cause of pain rather than symptom, long term

16. Chronic Pain Treatment Costs • Surgery = $40,000 – $100,000 • Physical Therapy = $50 – $350 per session • Embryonic Stem Cells = only research purposes • Pluripotent Stem Cells = $8,000 – $10,000 • Mesenchymal Stem Cells = $7,000 – $300,000 • Platelet Rich Plasma (PRP) = $1,400 – $2,000

17. What Treatment Should You Choose?

18. 970-927-0308 | aspenintegrativemedicine.com